Fluconazole

Fluconazole is a broad-spectrum antifungal medication used to treat a variety of fungal infections, including those caused by Candida species, cryptococcosis, and certain types of fungal meningitis. It functions by inhibiting the enzyme lanosterol 14-alpha-demethylase, which is crucial for the synthesis of ergosterol, an essential component of fungal cell membranes. By disrupting the production of ergosterol, Fluconazole impairs fungal cell membrane integrity, leading to cell death and resolution of the infection. It is commonly administered orally in tablet or liquid form, but can also be given intravenously for severe infections. Fluconazole is known for its favorable safety profile and high oral bioavailability, making it effective in treating both systemic and localized infections. However, it can interact with various medications and may cause side effects such as gastrointestinal disturbances, headache, or liver enzyme abnormalities. It is important for patients to use Fluconazole under the guidance of a healthcare provider, especially when used in conjunction with other medications or in individuals with liver impairment.